How does CBD work in the body?

The human body is a complex machine and the way it interacts with any compound, including cannabidiol (CBD), can be even more complex. Articles already published by Smart Nature refer that the endocannabinoid system it plays a fundamental and varied role within the body, as it consists of a huge network of cannabinoid receptors that spread throughout the body. The human endocannabinoid system releases endocannabinoids, which interact with receptors found in virtually every tissue in our body. 

CBD is a phytocannabinoid that can be extracted from cannabis. All cannabinoids, including CBD, produce effects in the body by binding to certain receptors belonging to the endocannabinoid system. Currently, CBD is considered as one of the most popular health supplements in the world as it can help patients or people with specific problems, both physical and psychological. Some of the constraints that CBD consumption can alleviate are: eating disorders, diabetes, schizophrenia, bipolarity, insomnia, post-traumatic stress disorder, among others.

CBD activates adenosine receptors when it comes into contact with the central nervous system. These receptors, when activated, begin to regulate cardiovascular functions, coronary blood flow and myocardial oxygen consumption. These receptors are responsible for the sensation of tension, pain, anxiety, shortness of breath or tightness in the chest. In turn, these receptors are important brain regulators of other neurotransmitters, such as glutamate or dopamine. This last substance is responsible for producing pleasant sensations in our body, in addition to influencing sleep, mood, attention, memory and voluntary movement.

In short, this system works with the objective of providing balance to tissues, including the heart, digestive, endocrine, immune, nervous and reproductive systems, keeping them in a neutral state.

It should be noted that cannabis is not only made up of THC and CBD, there are also other active compounds, such as:

  • Cannabinol (CBN): is a psychotropic cannabinoid. This metabolite of tetrahydrocannabinol (THC) interacts with CB1 and CB2 receptors, but with lower affinity than THC.
  • Cannabigerol (CBG): is a non-psychoactive cannabinoid found in plants ofcannabis. This active is found in greater concentration in hemp, while cannabis grown for consumption contains it to a lesser extent.
  • Cannabicyclol (CBL): is a non-psychoactive cannabinoid found in cannabis. CBL is a degradative product like cannabinol, as light converts CBC to CBL. 
  • Cannabichromene (CBC): is an abundant natural phytocannabinoid and is believed to be the second most abundant cannabinoid in cannabis. This active produces analgesic and anti-inflammatory effects in rodents, and has the potential to treat several inflammatory and gastrointestinal disorders in humans.

Factors Influencing CBD Absorption

There are several factors that influence the effectiveness of CBD:

  • CBD Quality:
    Not all CBD products are created equal. Some lower quality products not only contain lesser amounts of low quality cannabidiol, they may also include ingredients that reduce their bioavailability. Thus, it is necessary to find out about the quality of the compost you intend to consume. The best products with CBD not only indicate the precise amount of CBD in their composition (the CBD being obtained from sustainably cultivated hemp plants), but are also tested to prove the absence of harmful agents to health by making these tests available for whoever wants to prove it (with Smart Nature does it with their products).
  • Body:
    As mentioned above, each human being is unique. The body's metabolism involves the breakdown and synthesis of compounds to help the body function properly, and the composition of each also plays an important role in how it reacts. The same dose and quality when given to two different people can have different impacts. 
  • Medical condition:
    The doses of CBD to take vary for each medical condition, and you may need more CBD to fight a serious or chronic condition than a mild one.

CBD only works when the body absorbs it, as CBD has to make its way from the point of entry into the bloodstream where it interacts with cannabinoid and non-cannabinoid receptors. The speed and level of absorption into the bloodstream is dictated by the method of consumption, and the faster it reaches the bloodstream, the greater the level of bioavailability.

What affects the length of stay in the system?

There are a few variables to consider when thinking about how long the CBD remains in the system.

  • Usage time:
    As with most other substances, the higher the dose, the longer the CBD will remain in your system. However, the dose must always be suitable for each situation.
  • Frequency of use:
    Frequency of use also determines how long CBD remains in the body. CBD builds up over time if used regularly. It is therefore recommended to use it for at least one week.
  • Body:
    As already mentioned, each organism is different and body mass index, water content and metabolism are some of the factors that influence how long CBD remains in the system.
  • Food:
    Food is also a key factor in this theme, as its quality and quantity influence the duration of the CBD. When taking CBD on an empty stomach, this compound is metabolized and eliminated faster than when taken on a full stomach, which slows down digestion.
  • Method of use:
    The method you use when taking CBD affects everything from the onset and duration of effects to how long it stays in your system. 

CBD manifests itself differently in each person, affecting in different ways, requiring professional advice to indicate the right dose for each individual, also meeting their needs and physical and metabolic conditions, in order to provide the effect desired. 

At Smart Nature you can find a wide range of CBD-based products that can meet your physical needs:

  1. https://cbeuhd.com/pt-pt/os-efeitos-do-cbd-canabidiol-no-sono/
  2. https://www.naturicious.pt/cbd-101/cbd-dormir/
  3. https://www.medicalnewstoday.com/articles/cbd-and-sleep
  4. http://www.blogdotoninho.com.br/o-que-ja-se-sabe-sobre-canabidiol-cbd-e-sono/ 
  5. https://hemppedia.org/pt/como-para-insonia/ 
  6. https://wayofleaf.com/cbd/101/can-cbd-replace-xanax
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